Research is focused on cell and developmental biology, tissue engineering, experimental morphology, experimental medicine, neurosciences and clinical anatomy.
More specifically, research is focused on genes influencing limb and musculature patterning, on the role of c-Myb transcription factor in regulation of the epithelial-mesenchymal transition in the neural crest, on isolation and characterization of neural crest stem cells from adult human hair follicles, on the role of Shh signaling in branchial vessel formation and remodeling, on the influence of hypoxia on developing vessels and heart and on the role of Plzf expression in limb development.
Further research studies the phenotype including glycophenotype and gap junctions of squamous cell epithelia under normal and pathological conditions (cancer, psoriasis). The epidermal stem cells as well as their epithelial-mesenchymal interactions are investigated under normal conditions, during wound healing and in cancer.
The development of the heart including the pathogenesis of embryonic heart failure is studied under both normal and altered hemodynamic conditions to identify molecular mechanisms regulating the proliferation of cardiomyocytes, differentiation of conduction system and the role of stem cells in heart development. The role of antisense approach to decrease in-stent restenosis in porcine coronary arteries is being explored by targeting connexin 43.
On the clinical side we are focused on development of ligamentous apparatus and its relation to growing skeleton. Neuroscience topic deals with volumetry of basal ganglia in normal anatomical preparations and in MRI of patient with Parkinson disease, Alzheimer disease and carotid artery occlusion. Especially amygdala is in the focus of attention.
stem cells, neural crest cells, tumor microenvironment, epithelial-mesenchymal interaction, tissue engineering, angiogenesis, endogenous lectin, sugar code, Merkel nerve ending, myogenesis, c-Myb, limb patterning, basal ganglia, neuroimaging, heart development, cardiac conducting system, cardiomyocyte, heart failure, lymphology, in-stent restenosis
Kolesova H, Roelink H, Grim M: Sonic hedgehog is required for the assembly and remodeling of branchial arch blood vessels. Dev Dyn 237: 1923 – 34, 2008
Nanka O, Krizova P, Fikrle M, Tuma M, Blaha M, Grim M, Sedmera D: Abnormal Myocardial and Coronary Vasculature Development in Experimental Hypoxia. Anat Rec (Hoboken) 291: 1187 – 99, 2008
Sedmera D, Harris BS, Grant E, Zhang N, Jourdan J, Kurkova D, Gourdie RG: Cardiac expression patterns of endothelin-converting enzyme (ECE): implications for conduction system development. Dev Dyn 237: 1746 – 53, 2008
Damon BJ, Remond MC, Bigelow MR, Trusk TC, Xie W, Perucchio R, Sedmera D, Denslow S, Thompson RP“ Patterns of muscular strain in the embryonic heart wall. Dev Dyn 238:1535-1546, 2009
deAlmeida A, Sedmera D: Fibroblast Growth Factor-2 regulates proliferation of cardiac myocytes in normal and hypoplastic left ventricles in the developing chick. Cardiol Young 19:159-169, 2009
Liska F, Snajdr P, Sedova L, Seda O, Chylikova B, Slamova P, Krejci E, Sedmera D, Grim M, Krenova D, Kren V: Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Dev Dyn 238:673-684, 2009
Nanka O, Grim M: Utváření cévního řečiště: přehled molekulárních mechanismů a možnosti terapeutického ovlivnění. Čas Lék Čes. 148, 158-162, 2009
Sedmera D: Pathways to embryonic heart failure. Am J Physiol Heart Circ Physiol. Nov. 297: H1578 – 9, 2009
Liska F, Gosele C, Rivkin E, Tres L, Cardoso MC, Domaing P, Krejcí E, Snajdr P, Lee-Kirsch MA, de Rooij DG, Kren V, Krenová D, Kierszenbaum AL, Hubner N.: Rat hd Mutation Reveals an Essential Role of Centrobin in Spermatid Head Shaping and Assembly of the Head-Tail Coupling Apparatus.; Biol Reprod. 81:1196 – 205, 2009
Krejčí E, Grim M Isolation and characterization of neural crest stem cells from adult human hair follicles. Fol. Biol. (Praha) 56:149-57, 2010
Valasek P, Theis S., Krejci E., Grim M., Maina F., Huang R., Patel K.: Somitic origin of the medial border of the mammalian scapula and its homology to the avian scapula blade. J Anat 216: 482 – 8, 2010
Šnajdr P, Grim M, Liška F. /HOX geny a vývoj končetin v klinické medicíně i v experimentu. Časopis lékařů českých 149: 4 – 9, 2010
Liška F, Šnajdr P, Stricker S, Gosele C, Křenová D,Hubner N.Impairment of Sox9 expression in limb buds of rats homozygous for hypodactyly mutation, /Folia Biologica (Praha) 56: 58 – 65, 2010
Sankova B, Machalek J, Sedmera D: Effects of mechanical loading on early conduction system differentiation in the chick. Am J Physiol Heart Circ Physiol 298: H1571-1576, 2010
Dvořánková, B., Lacina, L., Smetana, K., Jr., Lensch, M., Manning, J., C., André, S., Gabius, H.-J.: Human galectin-2: nuclear presence in vitro and its modulation by quiescence/stress factors. Histol. Histopathol. 23: 167-168, 2008
Gál, P., Toporcer, T., Grendel, T., Vidová, Z., Smetana, K., Jr., Dvořánková, B., Gál, T., Mozek, Š., Lenhardt, L., Longauer, F., Sabol, M., Sabo, J., Bačkor, M.: Effect of Atropa belladonna L. on skin wound healing: Biomechanical and histological study in rats and in vitro study in keratinocytes, 3T3 fibroblasts, and human umbilical vein endothelial cells. Wound Rep Regen. 17: 378-386, 2009
Kideryová, L., Lacina, L., Dvořánková, B., Štork, J., Čada, Z., Szabo, P., André, S., Kaltner, H., Gabius, H.-J., Smetana K., Jr.: Phenotypic characterization of human keratinocytes in coculture reveals differential effects of fibroblasts from benign fibrous histiocytoma (dermatofibroma) as compared to cells from its malignant form and to normal fibroblasts. J. Dermatol. Sci. 55: 18-26, 2009
Plzák, J., Lacina, L., Chovanec, M., Dvořánková, B., Szabo, P., Čada, Z., Smetana, K., Jr.: Epithelial – stromal interaction in squamous cell epithelium – derived tumors: an important new player in the control of tumor biological properties. Anticancer Res. 30: 455-462, 2010
Smetana, K., Jr., Dvořánková, B., Lacina, L., Čada, L., Vonka, V.: Human hair follicle and interfollicular keratinocyte reaktivity to mouse HPV16-transformed cells: An in vitro study. Oncol Rep. 20: 75-80, 2008
Strnad, H., Lacina, L., Kolář, M., Čada, Z., Vlček, Č., Dvořánková, B., Betka, J., Plzák, J., Chovanec, M., Šáchová, J., Valach, J., Urbanová, M., Smetana, K., Jr.: Head and neck squamous cancer fibroblasts produce growth factors influencing phenotype of normal human keratinocytes. Histochem. Cell Biol. 133: 201-211, 2010
Petrovova E, Sedmera D, Lesnik F, Luptakova L.. Bendiocarbamate effect on liver and central nervous system in the chick embryo. J Environ Sci Health B 44:383 - 388, 2009
Petrovova E, Sedmera D, Misek I, Lesnik F, Luptakova L. Bendiocarbamate toxicity in the chick embryo. Folia Biol (Praha) 55:61-65, 2009
Ježek, P., Nekvasil, M., Škobisová, E., Urbánková, E., Jirsa, M., Zadinová, M., Poučková, P., Klepáček, I.: Experimental photodynamic therapy with MESO-tetrakisphenylporphyrine (TPP) in liposomes leads to disintegration of human amelanotic melanoma implanted to nude mice International Journal of Cancer, 103, 2003, s. 693-702.
Renno, W. M., Saleh, F., Klepáček, I., Al-Khaledi, G., Ismael, H., Asfar, S.: Green tea pain modulating effect in sciatic nerve chronic constriction injury rat model. Nutritional Neuroscience, 9, 2006, s. 41-47.
Vaněčková, Manuela; Seidl, Zdeněk; Goldová, Barbara; Vítková, Ivana; Kotlas, Jaroslav; Petrovický, Pavel; Calda, Pavel. Post-mortem magnetická rezonance plodu - technika vyšetření. [kazuistika]. Česká radiologie, 2008, 62, 4, s. 384-387, 2008.
Bechyně, K.; Varjassyová, A.; Lodinská, D.; Vyhnálek, M.; Bojar, M.; Brabec, Jiří; Petrovický, Pavel; Seidl, Zdeněk; Schenk, I.; Hort, J.: Vztah atrofie amygdaly a dalších vybraných mozkovýchz struktur k emocionální agnozii u Alzheimerovy nemoci. Česk Slov Neurol, 71, 6, s. 675-681, 2008
Bartoš, R., Sameš, M., Zolal, A., Radovnický, T., Hejčl, A., Vachata, P., Cihlář, F., Bejšovec, D., Petrovický, P. : Resekce inzulárních gliomů – volumetrické měření radikality. Česk. Slov Neurol. 72
Brabec J, Rulseh A, Pala A, Guerreiro H, Buskova J, Petrovicky P, Krasensky J, Seidl Z, Sonka K.: Volume of the amygdala is reduced in patients with narcolepsy – a structural MRI study. 6th International Symposium on narcolepsy; Monte Verita, Ascona, Switzerland 27.9.-2.10.2009.
Vachata, P., Petrovický, P., Sameš, M.: Agenese, aplazie a hypoplasie arteria carotis interna. Česk Slov Neurol N, 72: 470-.474, 2009
Brabec, J., Rulseh, A., M., Hoyt, B., Horinek, D., Hort, J., Petrovicky, P.: Volumetry of the human amygdala - an anatomical study. Psychiatry Research: Neuroimaging 182/1:67-72, 2010
Eliska O, Eliskova M, Miller AJ.: The absence of lymphatics in normal and atherosclerotic coronary arteries in man: a morphologic study. Lymphology. 2006, 39: 76-83.
Pavlista D, Eliska O, Duskova M, Zikan M, Cibula D.: Localization of the sentinel node of the upper outer breast quadrant in the axillary quadrants. Ann Surg Oncol. 2007, 14:633-7.
Šedý J, Naňka 0, Špačková J, Jarolím L: Clinical Implications of a Close Vicinity of Nervus Dorsalis Penis/Clitoridis and Os Pubis. J Sex Med 5: 1572 – 1581, 2008
Jarolím L, Sedý J, Schmidt M, Naňka O, Foltán R, Kawaciuk I.: Gender Reassignment Surgery in Male-to-Female Transsexualism: A Retrospective 3-Month Follow-up Study with Anatomical Remarks. J Sex Med. 6: 1635 – 1644, 2009
Hubka P, Spacková J, Nanka O, Masata J. Existence of the preperitoneal fatty plug and hernia in obturator canal. Ceska Gynekol 75: 208 – 211, 2010
Hubka P, Nanka O, Martan A, Grim M, Svabik K, Zvarova J, Masata J: Anatomical study of position of the TVT-O to the obturator nerve influenced by the position of the legs during the procedure - based upon findings at formalin embalmed and fresh frozen bodies. Arch Gynecol Obstet 2010 Nov 27 (Epub ahead of print)
Hubka P, Nanka O, Martan A, Grim M, Zvarova J, Masata J.: TVT-S in the U position-anatomical study. Int Urogynecol J Pelvic Floor Dysfunct. 2010 Aug 27 (Epub ahead of print)
Hubka P,Mašata J, Naňka O, Martan A: Bezpečnost TVT-O z anatomického pohledu. Česká gynekologie 75: 471-473, 2010
Halata Z, Grim M, Baumann KI: Current understanding of Merkel cells, touch reception and the skin. Expert Rev. Dermatol. 5: 109–116, 2010.
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