Degrees

1989 - 1996: Charles University, First Faculty of Medicine - MD.
1996 - 1998: Universite de Lausanne, Faculty of Sciences - Ph.D.
2006 - First Faculty of Medicine, Charles University - Associate Professor
2009 - The Czech Academy of Sciences (CAS) - DSc.
2012 - First Faculty of Medicine, Charles University - Professor

Professional history

1996 - Institute of Experimental Medicine, CAS - Research Assistant
1996 - 1998: Institute of Physiology, University Of Lausanne - Assistant
1998 - 2000: Department of Cell Biology and Anatomy, Mediccal University of South Carolina - Postdoctoral Fellow
2000 - 2005: Department of Cell Biology and Anatomy, Mediccal University of South Carolina - Assistant Professor
2006 - 2008: Laboratory of Cardiovascular Morphogenesis, Institute of Animal Physiology and Genetics, CAS - Laboratory Head
2006 - 2012: Institute of Anatomy, First Faculty of Medicine, Charles University - Associate Professor
2008 - present: Laboratory of Cardiovascular Morphogenesis, Institute of Physiology, CAS - Laboratory Head
2012 - present: Institute of Anatomy, First Faculty of Medicine, Charles University - Professor

Scholarships

1994 - Department of Anatomy and Embryology, Universite Libre de Bruxelles, Belgie
1994 - 1995: Institute of Histology, Université de Lausanne, Switzerland

Ph.D. position available

PF 2020

Haiku

Beware of the crocodile wave!

Select publications

2018

Petrovova E, Giretova M, Kvasilova A, Benada O, Danko J, Medvecky L, Sedmera D. Preclinical alternative model for analysis of porous scaffold biocompatibility in bone tissue engineering. ALTEX. 2018 Nov 23. doi: 10.14573/altex.1807241. [Epub ahead of print] PMID: 30474687

Neckář J, Hsu A, Hye Khan MA, Gross GJ, Nithipatikom K, Cyprová M, Benák D, Hlaváčková M, Sotáková-Kašparová D, Falck JR, Sedmera D, Kolář F, Imig JD. Infarct size-limiting effect of epoxyeicosatrienoic acid analog EET-B is mediated by hypoxia-inducible factor-1? via downregulation of prolyl hydroxylase 3. Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1148-H1158. doi: 10.1152/ajpheart.00726.2017. Epub 2018 Aug 3. PMID: 30074840

Kvasilova A, Gregorovicova M, Kundrat M, Sedmera D. HNK-1 in Morphological Study of Development of the Cardiac Conduction System in Selected Groups of Sauropsida. Anat Rec (Hoboken). 2018 Oct 10. doi: 10.1002/ar.23925. [Epub ahead of print] PMID: 30306736

Vicente Steijn R, Sedmera D, Blom NA, Jongbloed M, Kvasilova A, Nanka O. Apoptosis and epicardial contributions act as complementary factors in remodeling of the atrioventricular canal myocardium and atrioventricular conduction patterns in the embryonic chick heart. Dev Dyn. 2018 Sep;247(9):1033-1042. doi: 10.1002/dvdy.24642. Epub 2018 Aug 28. PMID: 30152577

Kolesová H, Bartoš M, Hsieh WC, Olejníčková V, Sedmera D. Novel approaches to study coronary vasculature development in mice. Dev Dyn. 2018 Aug;247(8):1018-1027. doi: 10.1002/dvdy.24637. Epub 2018 Jul 1. PMID: 29770532

Gregorovicova M, Sedmera D, Jensen B. Relative position of the atrioventricular canal determines the electrical activation of developing reptile ventricles. J Exp Biol. 2018 Jun 7;221(Pt 11). pii: jeb178400. doi: 10.1242/jeb.178400. PMID: 29674379

Cerychova R, Bohuslavova R, Papousek F, Sedmera D, Abaffy P, Benes V, Kolar F, Pavlinkova G. Adverse effects of Hif1a mutation and maternal diabetes on the offspring heart. Cardiovasc Diabetol. 2018 May 12;17(1):68. doi: 10.1186/s12933-018-0713-0. PMID: 29753320 Free PMC Article

Jensen B, Boukens BJ, Crossley DA 2nd, Conner J, Mohan RA, van Duijvenboden K, Postma AV, Gloschat CR, Elsey RM, Sedmera D, Efimov IR, Christoffels VM. Specialized impulse conduction pathway in the alligator heart. Elife. 2018 Mar 22;7. pii: e32120. doi: 10.7554/eLife.32120. PMID: 29565246

Pesevski Z, Kvasilova A, Stopkova T, Nanka O, Drobna Krejci E, Buffinton C, Kockova R, Eckhardt A, Sedmera D. Endocardial Fibroelastosis is Secondary to Hemodynamic Alterations in the Chick Embryonic Model of Hypoplastic Left Heart Syndrome. Dev Dyn. 2018 Mar;247(3):509-520. doi: 10.1002/dvdy.24521. Epub 2017 Jun 15. PMID:28543854

Gregorovičová M, Kvasilová A, Sedmera D. Ossification Pattern in Forelimbs of the Siamese Crocodile (Crocodylus siamensis): Similarity in Ontogeny of Carpus Among Crocodylian Species. Anat Rec (Hoboken). 2018 Jan 30. doi: 10.1002/ar.23792. [Epub ahead of print] PMID:29381837

Eckhardt A, Kulhava L, Miksik I, Pataridis S, Hlavackova M, Vasinova J, Kolar F, Sedmera D, Ostadal B. Proteomic analysis of cardiac ventricles: baso-apical differences. Mol Cell Biochem. 2018 Aug;445(1-2):211-219. doi: 10.1007/s11010-017-3266-8. Epub 2018 Jan 4. PMID:29302836

Mikšík I, Paradis S, Eckhardt A, Sedmera D. Analysis of Siamese Crocodile (Crocodylus siamensis) Eggshell Proteome. Protein J. 2018 Feb;37(1):21-37. doi: 10.1007/s10930-017-9750-x. PMID:29168058

2017

Sedmera D, Vostárek F. [The contemporary view of the cardiac conduction system]. Cas Lek Cesk. 2017 Winter;156(8):417-421. Czech. PMID:29368524

Tian X, Li Y, He L, Zhang H, Huang X, Liu Q, Pu W, Zhang L, Li Y, Zhao H, Wang Z, Zhu J, Nie Y, Hu S, Sedmera D, Zhong TP, Yu Y, Zhang L, Yan Y, Qiao Z, Wang QD, Wu SM, Pu WT, Anderson RH, Zhou B. Identification of a hybrid myocardial zone in the mammalian heart after birth. Nat Commun. 2017 Jul 20;8(1):87. doi: 10.1038/s41467-017-00118-1. PMID:28729659

Franco D, Sedmera D, Lozano-Velasco E. Multiple Roles of Pitx2 in Cardiac Development and Disease. J Cardiovasc Dev Dis. 2017 Oct 11;4(4). pii: E16. doi: 10.3390/jcdd4040016. Review. PMID:29367545

2016

Sedmera D, Neckar J, Benes J Jr, Pospisilova J, Petrak J, Sedlacek K, Melenovsky V. Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload. Front Physiol. 2016 Aug 25;7:367.

Vrbacký M, Kovalčíková J, Chawengsaksophak K, Beck IM, Mráček T, Nůsková H, Sedmera D, Papoušek F, Kolář F, Sobol M, Hozák P, Sedlacek R, Houštěk J. Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice. Hum Mol Genet. 2016 Aug 31. pii: ddw295. [Epub ahead of print]

Kolesová H, Čapek M, Radochová B, Janáček J, Sedmera D. Comparison of different tissue clearing methods and 3D imaging techniques for visualization of GFP-expressing mouse embryos and embryonic hearts. Histochem Cell Biol. 2016 Aug;146(2):141-52.

Vostarek F, Svatunkova J, Sedmera D. Acute temperature effects on function of the chick embryonic heart. Acta Physiol (Oxf). 2016 Aug;217(4):276-86.

Krejci E, Pesevski Z, Nanka O, Sedmera D. Physiological role of FGF signaling in growth and remodeling of developing cardiovascular system. Physiol Res. 2016 Jul 18;65(3):425-35.

Kockova R, Kacer P, Pirk J, Maly J, Sukupova L, Sikula V, Kotrc M, Barciakova L, Honsova E, Maly M, Kautzner J, Sedmera D, Penicka M. Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy. Circ J. 2016 Apr 25;80(5):1202-9.

Pérez-Pomares JM, de la Pompa JL, Franco D, Henderson D, Ho SY, Houyel L, Kelly RG, Sedmera D, Sheppard M, Sperling S, Thiene G, van den Hoff M, Basso C. Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology--a position statement of the development, anatomy, and pathology ESC Working Group. Cardiovasc Res. 2016 Feb 1;109(2):204-16.

2015

Sedmera D, Kockova R, Vostarek F, Raddatz E. Arrhythmias in the developing heart.
Acta Physiol (Oxf). 2015 Feb;213(2):303-20.

Petrovova E, Purzyc H, Mazensky D, Luptakova L, Torma N, Sopoliga I, Sedmera D. Morphometric alterations, steatosis, fibrosis and active caspase-3 detection in carbamate bendiocarb treated rabbit liver. Environ Toxicol. 2015 Feb;30(2):212-22.

2014

Sedmera D, Kockova R, Vostarek F, Raddatz E. Arrhythmias in the developing heart. Acta Physiol (Oxf). 2015 Feb;213(2):303-20. Review.

Tenin G, Clowes C, Wolton K, Krejci E, Wright JA, Lovell SC, Sedmera D, Hentges KE. Erbb2 is required for cardiac atrial electrical activity during development. PLoS One. 2014 Sep 30;9(9):e107041.

Hejnova L, Hahnova K, Kockova R, Svatunkova J, Sedmera D, Novotny J. Adenylyl cyclase signaling in the developing chick heart: the deranging effect of antiarrhythmic drugs. Biomed Res Int. 2014;2014:463123.

Vostarek F, Sankova B, Sedmera D. Studying dynamic events in the developing myocardium. Prog Biophys Mol Biol. 2014 Aug;115(2-3):261-9.

Ostadal B, Ostadalova I, Kolar F, Sedmera D. Developmental determinants of cardiac sensitivity to hypoxia. Can J Physiol Pharmacol. 2014 Jul;92(7):566-74.

Sedmera D, Gourdie RG. Why do we have Purkinje fibers deep in our heart? Physiol Res. 2014;63 Suppl 1:S9-18. Review.

Bohuslavova R, Kolar F, Sedmera D, Skvorova L, Papousek F, Neckar J, Pavlinkova G. Partial deficiency of HIF-1? stimulates pathological cardiac changes in streptozotocin-induced diabetic mice. BMC Endocr Disord. 2014 Feb 6;14:11.

Benes J Jr, Ammirabile G, Sankova B, Campione M, Krejci E, Kvasilova A, Sedmera D. The role of connexin40 in developing atrial conduction. FEBS Lett. 2014 Apr 17;588(8):1465-9.

Sochman J, Peregrin JH, Pavcnik D, Uchida BT, Timmermans HA, Sedmera D, Benada O, Kofronova O, Keller FS, Rosch J. Reverse endoventricular artificial obturator in tricuspid valve position. Experimental feasibility research study. Physiol Res. 2014;63(2):157-65.

A. HAQUE, B. ŠANKOVÁ, A. KVASILOVÁ, E. KREJČÍ, D. SEDMERA. Does Folic Acid Supplementation Rescue Defects in ECE-1-Deficient Mouse Embryos? Folia Biol (Praha). 2014;60(5):244-51.

Sedmera D. New role for endothelin signalling during development. Acta Physiol (Oxf). 2014 Feb;210(2):236-8.

List of all publications via PubMed

Collaboration with The Czech Academy of Sciences

Main topics and interest

Developmental biology
Congenital anomaliest
Cardiac conduction system