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Prof. David Sedmera, MD., D.Sc.

Prof. MUDr. David Sedmera, D.Sc. Mailing adress

Institute of Anatomy,
First Faculty of Medicine,
Charles University
U nemocnice 3,
128 00 Praha 2
Czech Republic

phone: +420 224 965 941


August 14, 1971


1989-1996 - Charles University, 1st Faculty Of Medicine - MD.
1996-1998 - Universite de Lausanne, Faculty of Sciences - Ph.D.
2009 -Academy of Sciences of Czech Republic - D.Sc.

Professional history

1996 - Institute of Experimental Medicine, Czech Academy of Sciences – Research Assistant
1996 - 1998 - Institute of Physiology, University Of Lausanne - Assistant
1998 - 2000 – Department of Cell Biology and Anatomy, Mediccal University of South Carolina - Postdoctoral Fellow
2000 - 2005 - Department of Cell Biology and Anatomy, Mediccal University of South Carolina – Assistant Professor
2006 – present - Institute of Anatomy, 1st Medical Faculty, Charles University – Associate Professor
2008 - present - Laboratory Head, Laboratory of Cardiovascular Morphogenesis, Institute of Physiology
2006-2008 Laboratory Head, Laboratory of Cardiovascular Morphogenesis, Institute of Animal Physiology and Genetics
2009 - present The Academy of Sciences of the Czech Republic - D.Sc.


1994 - Oddělení Anatomie a Embryologie, Universite Libre de Bruxelles, Belgie
1994 - 1995 - Ústav Histologie, Université de Lausanne, Switzerland

Select publications


Sedmera D, Watanabe M. 2006. Growing the coronary tree: the quail saga. Anat Rec A Discov Mol Cell Evol Biol 288:933-935. +

Sedmera D, Wessels A, Trusk TC, Thompson RP, Hewett KW, Gourdie RG. 2006. Changes in activation sequence of embryonic chick atria correlate with developing myocardial architecture. Am J Physiol Heart Circ Physiol 291:H1646-1652. +

Walle T, Walle UK, Sedmera D, Klausner M. 2006. Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: studies in bioengineered human tissue. Drug Metab Dispos 34:346-350.

Zhang N, Mustin D, Reardon W, Almeida AD, Mozdziak P, Mrug M, Eisenberg LM, Sedmera D. 2006. Blood-borne stem cells differentiate into vascular and cardiac lineages during normal development. Stem Cells Dev 15:17-28. +


Butcher JT, McQuinn TC, Sedmera D, Turner D, Markwald RR. 2007. Transitions in early embryonic atrioventricular valvular function correspond with changes in cushion biomechanics that are predictable by tissue composition. Circ Res 100:1503-1511.

Butcher JT, Sedmera D, Guldberg RE, Markwald RR. 2007b. Quantitative volumetric analysis of cardiac morphogenesis assessed through micro-computed tomography. Dev Dyn 236:802-809.

deAlmeida A, McQuinn T, Sedmera D. 2007. Increased ventricular preload is compensated by myocyte proliferation in normal and hypoplastic fetal chick left ventricle. Circ Res 100:1363-1370.

Gurjarpadhye A, Hewett KW, Justus C, Wen X, Stadt H, Kirby ML, Sedmera D, Gourdie RG. 2007. Cardiac neural crest ablation inhibits compaction and electrical function of conduction system bundles. Am J Physiol Heart Circ Physiol 292:H1291-1300.

McQuinn TC, Bratoeva M, Dealmeida A, Remond M, Thompson RP, Sedmera D. 2007. High-frequency ultrasonographic imaging of avian cardiovascular development. Dev Dyn., 236:3503-3513.


Gourdie RG, Sedmera D. 2008. Letter by Gourdie and Sedmera regarding article, "abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal-targeted deletion of Alk3/Bmpr1a receptor". Circulation 118:e106; author reply e107.

Nanka O, Krizova P, Fikrle M, Tuma M, Blaha M, Grim M, Sedmera D. 2008. Abnormal myocardial and coronary vasculature development in experimental hypoxia. Anat Rec (Hoboken) 291:1187-1199.

Sedmera D, Harris BS, Grant E, Zhang N, Jourdan J, Kurkova D, Gourdie RG. 2008. Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development. Dev Dyn 237:1746-1753.

Sedmera D, McQuinn T. 2008. Embryogenesis of the heart muscle. Heart Fail Clin 4:235-245.


Sedmera D: Pathways to embryonic heart failure. Am J Physiol Heart Circ Physiol. 297:H1578-9 (2009)

Damon BJ, Remond MC, Bigelow MR, Trusk TC, Xie W, Perucchio R, Sedmera D, Denslow S, and Thompson RP. Patterns of muscular strain in the embryonic heart wall. Dev Dyn 238: 1535-1546, 2009.

deAlmeida A and Sedmera D. Fibroblast Growth Factor-2 regulates proliferation of cardiac myocytes in normal and hypoplastic left ventricles in the developing chick. Cardiol Young 19: 159-169, 2009.

Liska F, Snajdr P, Sedova L, Seda O, Chylikova B, Slamova P, Krejci E, Sedmera D, Grim M, Krenova D, and Kren V. Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Dev Dyn 238: 673-684, 2009.

Petrovova E, Sedmera D, Lesnik F, and Luptakova L. Bendiocarb effect on liver and central nervous system in the chick embryo. J Environ Sci Health B 44: 383-388, 2009.

Petrovova E, Sedmera D, Misek I, Lesnik F, and Luptakova L. Bendiocarbamate toxicity in the chick embryo. Folia Biol (Praha) 55: 61-65, 2009.


Sankova B, Machalek J, and Sedmera D. Effects of mechanical loading on early conduction system differentiation in the chick. Am J Physiol Heart Circ Physiol 298: H1571-1576, 2010.

Sedmera D. Factors in ventricular and atrioventricular valve growth: An embryologist's perspective. Progress in Pediatric Cardiology 29: 11-14, 2010.


Benes J, Jr., Melenovsky V, Skaroupkova P, Pospisilova J, Petrak J, Cervenka L, and Sedmera D. Myocardial Morphological Characteristics and Proarrhythmic Substrate in the Rat Model of Heart Failure Due to Chronic Volume Overload. Anat Rec (Hoboken) 294:102-111, 2011

Sedmera D, Thompson RP. Myocyte proliferation in the developing heart. Dev Dyn 240(6): 1322-34, 2011.

Benes J, Kazdova L, Drahota Z, Houstek J, Medrikova D, Kopecky J, Kovarova N, Vrbacky M, Sedmera D, Strnad H, Kolar M, Petrak J, Benada O, Skaroupkova P, Cervenka L, Melenovsky V. Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats. Clin Sci (London) 121(1): 29-41, 2011.

Sedmera D. Function and form in the developing cardiovascular system. Cardiovasc Res 91(2): 252-9, 2011.

Melenovsky V, Benes J, Skaroupkova P, Sedmera D, Strnad H, Kolar M, Vlcek C, Petrak J, Benes J Jr, Papousek F, Oliyarnyk O, Kazdova L, Cervenka L. Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats. Mol Cell Biochem 354(1-2): 83-96, 2011.

Petrak J, Pospisilova J, Sedinova M, Jedelsky P, Lorkova L, Vit O, Kolar M, Strnad H, Benes J, Sedmera D, Cervenka L and Melenovsky V. Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2. Proteome Science 9(1):69, 2011.


Ammirabile G, Tessari A, Pignataro V, Szumska D, Sardo FS, Benes J, Jr., Balistreri M, Bhattacharya S, Sedmera D, Campione M. 2012. Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium. Cardiovasc Res 93:291-301.

Krejci E, Pesevski Z, DeAlmeida AC, Mrug M, Fresco VM, Argraves WS, Barth JL, Cui X, Sedmera D. 2012. Microarray analysis of normal and abnormal chick ventricular myocardial development. Physiol Res 61 Suppl 1:S137-144.

Petrovova E, Sedmera D, Luptakova L, Mazensky D, Danko J. 2012. Chick development and high dose of bendiocarb. J Environ Sci Health A Tox Hazard Subst Environ Eng 47:1312-1318.

Sankova B, Benes J, Jr., Krejci E, Dupays L, Theveniau-Ruissy M, Miquerol L, Sedmera D. 2012. The effect of connexin40 deficiency on ventricular conduction system function during development. Cardiovasc Res 95:469-479.


Buffinton CM, Faas D, Sedmera D. 2013. Stress and strain adaptation in load-dependent remodeling of the embryonic left ventricle. Biomech Model Mechanobiol.

de la Rosa AJ, Dominguez JN, Sedmera D, Sankova B, Hove-Madsen L, Franco D, Aranega A. 2013. Functional suppression of Kcnq1 leads to early sodium channel remodeling and cardiac conduction system dysmorphogenesis. Cardiovasc Res.

Kockova R, Svatunkova J, Novotny J, Hejnova L, Ostadal B, Sedmera D. 2013. Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo. Am J Physiol Heart Circ Physiol 304:H895-902.

Bohuslavova R, Skvorova L, Sedmera D, Semenza GL, Pavlinkova G. 2013. Increased susceptibility of HIF-1alpha heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. J Mol Cell Cardiol 60C:129-141.

List of all publications via PubMed

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Main topics and interest

Developmental biology
Congenital anomaliest
Cardiac conduction system

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