Degrees

1989-1996 - Charles University, 1st Faculty Of Medicine - MD.
1996-1998 - Universite de Lausanne, Faculty of Sciences - Ph.D.
2009 -Academy of Sciences of Czech Republic - D.Sc.

Professional history

1996 - Institute of Experimental Medicine, Czech Academy of Sciences – Research Assistant
1996 - 1998 - Institute of Physiology, University Of Lausanne - Assistant
1998 - 2000 – Department of Cell Biology and Anatomy, Mediccal University of South Carolina - Postdoctoral Fellow
2000 - 2005 - Department of Cell Biology and Anatomy, Mediccal University of South Carolina – Assistant Professor
2006 – present - Institute of Anatomy, 1st Medical Faculty, Charles University – Associate Professor
2008 - present - Laboratory Head, Laboratory of Cardiovascular Morphogenesis, Institute of Physiology
2006-2008 Laboratory Head, Laboratory of Cardiovascular Morphogenesis, Institute of Animal Physiology and Genetics
2009 - present The Academy of Sciences of the Czech Republic - D.Sc.

Scholarships

1994 - Oddělení Anatomie a Embryologie, Universite Libre de Bruxelles, Belgie
1994 - 1995 - Ústav Histologie, Université de Lausanne, Switzerland

Select publications

2006

Sedmera D, Watanabe M. 2006. Growing the coronary tree: the quail saga. Anat Rec A Discov Mol Cell Evol Biol 288:933-935. +

Sedmera D, Wessels A, Trusk TC, Thompson RP, Hewett KW, Gourdie RG. 2006. Changes in activation sequence of embryonic chick atria correlate with developing myocardial architecture. Am J Physiol Heart Circ Physiol 291:H1646-1652. +

Walle T, Walle UK, Sedmera D, Klausner M. 2006. Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: studies in bioengineered human tissue. Drug Metab Dispos 34:346-350.

Zhang N, Mustin D, Reardon W, Almeida AD, Mozdziak P, Mrug M, Eisenberg LM, Sedmera D. 2006. Blood-borne stem cells differentiate into vascular and cardiac lineages during normal development. Stem Cells Dev 15:17-28. +

2007

Butcher JT, McQuinn TC, Sedmera D, Turner D, Markwald RR. 2007. Transitions in early embryonic atrioventricular valvular function correspond with changes in cushion biomechanics that are predictable by tissue composition. Circ Res 100:1503-1511.

Butcher JT, Sedmera D, Guldberg RE, Markwald RR. 2007b. Quantitative volumetric analysis of cardiac morphogenesis assessed through micro-computed tomography. Dev Dyn 236:802-809.

deAlmeida A, McQuinn T, Sedmera D. 2007. Increased ventricular preload is compensated by myocyte proliferation in normal and hypoplastic fetal chick left ventricle. Circ Res 100:1363-1370.

Gurjarpadhye A, Hewett KW, Justus C, Wen X, Stadt H, Kirby ML, Sedmera D, Gourdie RG. 2007. Cardiac neural crest ablation inhibits compaction and electrical function of conduction system bundles. Am J Physiol Heart Circ Physiol 292:H1291-1300.

McQuinn TC, Bratoeva M, Dealmeida A, Remond M, Thompson RP, Sedmera D. 2007. High-frequency ultrasonographic imaging of avian cardiovascular development. Dev Dyn., 236:3503-3513.

2008

Gourdie RG, Sedmera D. 2008. Letter by Gourdie and Sedmera regarding article, "abnormal conduction and morphology in the atrioventricular node of mice with atrioventricular canal-targeted deletion of Alk3/Bmpr1a receptor". Circulation 118:e106; author reply e107.

Nanka O, Krizova P, Fikrle M, Tuma M, Blaha M, Grim M, Sedmera D. 2008. Abnormal myocardial and coronary vasculature development in experimental hypoxia. Anat Rec (Hoboken) 291:1187-1199.

Sedmera D, Harris BS, Grant E, Zhang N, Jourdan J, Kurkova D, Gourdie RG. 2008. Cardiac expression patterns of endothelin-converting enzyme (ECE): Implications for conduction system development. Dev Dyn 237:1746-1753.

Sedmera D, McQuinn T. 2008. Embryogenesis of the heart muscle. Heart Fail Clin 4:235-245.

2009

Sedmera D: Pathways to embryonic heart failure. Am J Physiol Heart Circ Physiol. 297:H1578-9 (2009)

Damon BJ, Remond MC, Bigelow MR, Trusk TC, Xie W, Perucchio R, Sedmera D, Denslow S, and Thompson RP. Patterns of muscular strain in the embryonic heart wall. Dev Dyn 238: 1535-1546, 2009.

deAlmeida A and Sedmera D. Fibroblast Growth Factor-2 regulates proliferation of cardiac myocytes in normal and hypoplastic left ventricles in the developing chick. Cardiol Young 19: 159-169, 2009.

Liska F, Snajdr P, Sedova L, Seda O, Chylikova B, Slamova P, Krejci E, Sedmera D, Grim M, Krenova D, and Kren V. Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Dev Dyn 238: 673-684, 2009.

Petrovova E, Sedmera D, Lesnik F, and Luptakova L. Bendiocarb effect on liver and central nervous system in the chick embryo. J Environ Sci Health B 44: 383-388, 2009.

Petrovova E, Sedmera D, Misek I, Lesnik F, and Luptakova L. Bendiocarbamate toxicity in the chick embryo. Folia Biol (Praha) 55: 61-65, 2009.

2010

Sankova B, Machalek J, and Sedmera D. Effects of mechanical loading on early conduction system differentiation in the chick. Am J Physiol Heart Circ Physiol 298: H1571-1576, 2010.

Sedmera D. Factors in ventricular and atrioventricular valve growth: An embryologist's perspective. Progress in Pediatric Cardiology 29: 11-14, 2010.

2011

Benes J, Jr., Melenovsky V, Skaroupkova P, Pospisilova J, Petrak J, Cervenka L, and Sedmera D. Myocardial Morphological Characteristics and Proarrhythmic Substrate in the Rat Model of Heart Failure Due to Chronic Volume Overload. Anat Rec (Hoboken) 294:102-111, 2011

Sedmera D, Thompson RP. Myocyte proliferation in the developing heart. Dev Dyn 240(6): 1322-34, 2011.

Benes J, Kazdova L, Drahota Z, Houstek J, Medrikova D, Kopecky J, Kovarova N, Vrbacky M, Sedmera D, Strnad H, Kolar M, Petrak J, Benada O, Skaroupkova P, Cervenka L, Melenovsky V. Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats. Clin Sci (London) 121(1): 29-41, 2011.

Sedmera D. Function and form in the developing cardiovascular system. Cardiovasc Res 91(2): 252-9, 2011.

Melenovsky V, Benes J, Skaroupkova P, Sedmera D, Strnad H, Kolar M, Vlcek C, Petrak J, Benes J Jr, Papousek F, Oliyarnyk O, Kazdova L, Cervenka L. Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats. Mol Cell Biochem 354(1-2): 83-96, 2011.

Petrak J, Pospisilova J, Sedinova M, Jedelsky P, Lorkova L, Vit O, Kolar M, Strnad H, Benes J, Sedmera D, Cervenka L and Melenovsky V. Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2. Proteome Science 9(1):69, 2011.

List of all publications via PubMed

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Main topics and interest

developmental biology
heart development
myocyte proliferation
cardiac conduction system