česká vlajka united kingdom flag
logo 1.lfuk logo UK

INSTITUTE OF ANATOMY FIRST FACULTY OF MEDICINE
CHARLES UNIVERSITY IN PRAGUE

Prof. David Sedmera, MD., D.Sc.

Prof. MUDr. David Sedmera, D.Sc. Mailing adress

Institute of Anatomy,
First Faculty of Medicine,
Charles University
U nemocnice 3,
128 00 Prague 2
Czech Republic

david.sedmera@lf1.cuni.cz
phone: +420 224 965 941

Born

August 14, 1971

Degrees

1989-1996 - Charles University, First Faculty of Medicine - MD.
1996-1998 - Universite de Lausanne, Faculty of Sciences - Ph.D.
2009 - The Czech Academy of Sciences - D.Sc.

Professional history

1996 - Institute of Experimental Medicine, The Czech Academy of Sciences – Research Assistant
1996 - 1998 - Institute of Physiology, University Of Lausanne - Assistant
1998 - 2000 – Department of Cell Biology and Anatomy, Mediccal University of South Carolina - Postdoctoral Fellow
2000 - 2005 - Department of Cell Biology and Anatomy, Mediccal University of South Carolina – Assistant Professor
2006 – present - Institute of Anatomy, First Faculty of Medicine, Charles University – Associate Professor
2008 - present - Laboratory Head, Laboratory of Cardiovascular Morphogenesis, Institute of Physiology
2006-2008 Laboratory Head, Laboratory of Cardiovascular Morphogenesis, Institute of Animal Physiology and Genetics
2009 - present The Czech Academy of Sciences - D.Sc.

Scholarships

1994 - Department of Anatomy and Embryology, Universite Libre de Bruxelles, Belgie
1994 - 1995 - Institute of Histology, Université de Lausanne, Switzerland

Haiku

Select publications

2015

Sedmera D, Kockova R, Vostarek F, Raddatz E. 2015. Arrhythmias in the developing heart. Acta Physiol (Oxf). 2015 Feb;213(2):303-20.

2014

Tenin G, Clowes C, Wolton K, Krejci E, Wright JA, Lovell SC, Sedmera D, Hentges KE. 2014. Erbb2 is required for cardiac atrial electrical activity during development. PLoS One. 2014 Sep 30;9(9):e107041.

Hejnova L, Hahnova K, Kockova R, Svatunkova J, Sedmera D, Novotny J. 2014. Adenylyl cyclase signaling in the developing chick heart: the deranging effect of antiarrhythmic drugs. Biomed Res Int. 2014;2014:463123.

Vostarek F, Sankova B, Sedmera D. 2014. Studying dynamic events in the developing myocardium. Prog Biophys Mol Biol. 2014 Aug;115(2-3):261-9.

Ostadal B, Ostadalova I, Kolar F, Sedmera D. 2014. Developmental determinants of cardiac sensitivity to hypoxia. Can J Physiol Pharmacol. 2014 Jul;92(7):566-74.

Sedmera D, Gourdie RG. 2014. Why do we have Purkinje fibers deep in our heart? Physiol Res. 2014;63 Suppl 1:S9-18. Review.

A. HAQUE, B. ŠANKOVÁ, A. KVASILOVÁ, E. KREJČÍ, D. SEDMERA. 2014. Does Folic Acid Supplementation Rescue Defects in ECE-1-Deficient Mouse Embryos? Folia Biologica (Praha) 60, 244-251 (2014)

Bohuslavova R, Kolar F, Sedmera D, Skvorova L, Papousek F, Neckar J, Pavlinkova G. 2014. Partial deficiency of HIF-1? stimulates pathological cardiac changes in streptozotocin-induced diabetic mice. BMC Endocr Disord. 2014 Feb 6;14:11.

Benes J Jr, Ammirabile G, Sankova B, Campione M, Krejci E, Kvasilova A, Sedmera D. 2014. The role of connexin40 in developing atrial conduction. FEBS Lett. 2014 Apr 17;588(8):1465-9.

Sochman J, Peregrin JH, Pavcnik D, Uchida BT, Timmermans HA, Sedmera D, Benada O, Kofronova O, Keller FS, Rosch J. 2014. Reverse endoventricular artificial obturator in tricuspid valve position. Experimental feasibility research study. Physiol Res. 2014;63(2):157-65.

2013

Buffinton CM, Faas D, Sedmera D. 2013. Stress and strain adaptation in load-dependent remodeling of the embryonic left ventricle. Biomech Model Mechanobiol.

de la Rosa AJ, Dominguez JN, Sedmera D, Sankova B, Hove-Madsen L, Franco D, Aranega A. 2013. Functional suppression of Kcnq1 leads to early sodium channel remodeling and cardiac conduction system dysmorphogenesis. Cardiovasc Res.

Kockova R, Svatunkova J, Novotny J, Hejnova L, Ostadal B, Sedmera D. 2013. Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo. Am J Physiol Heart Circ Physiol 304:H895-902.

Bohuslavova R, Skvorova L, Sedmera D, Semenza GL, Pavlinkova G. 2013. Increased susceptibility of HIF-1alpha heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. J Mol Cell Cardiol 60C:129-141.

2012

Ammirabile G, Tessari A, Pignataro V, Szumska D, Sardo FS, Benes J, Jr., Balistreri M, Bhattacharya S, Sedmera D, Campione M. 2012. Pitx2 confers left morphological, molecular, and functional identity to the sinus venosus myocardium. Cardiovasc Res 93:291-301.

Krejci E, Pesevski Z, DeAlmeida AC, Mrug M, Fresco VM, Argraves WS, Barth JL, Cui X, Sedmera D. 2012. Microarray analysis of normal and abnormal chick ventricular myocardial development. Physiol Res 61 Suppl 1:S137-144.

Petrovova E, Sedmera D, Luptakova L, Mazensky D, Danko J. 2012. Chick development and high dose of bendiocarb. J Environ Sci Health A Tox Hazard Subst Environ Eng 47:1312-1318.

Sankova B, Benes J, Jr., Krejci E, Dupays L, Theveniau-Ruissy M, Miquerol L, Sedmera D. 2012. The effect of connexin40 deficiency on ventricular conduction system function during development. Cardiovasc Res 95:469-479.

2011

Benes J, Jr., Melenovsky V, Skaroupkova P, Pospisilova J, Petrak J, Cervenka L, and Sedmera D. Myocardial Morphological Characteristics and Proarrhythmic Substrate in the Rat Model of Heart Failure Due to Chronic Volume Overload. Anat Rec (Hoboken) 294:102-111, 2011

Sedmera D, Thompson RP. Myocyte proliferation in the developing heart. Dev Dyn 240(6): 1322-34, 2011.

Benes J, Kazdova L, Drahota Z, Houstek J, Medrikova D, Kopecky J, Kovarova N, Vrbacky M, Sedmera D, Strnad H, Kolar M, Petrak J, Benada O, Skaroupkova P, Cervenka L, Melenovsky V. Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats. Clin Sci (London) 121(1): 29-41, 2011.

Sedmera D. Function and form in the developing cardiovascular system. Cardiovasc Res 91(2): 252-9, 2011.

Melenovsky V, Benes J, Skaroupkova P, Sedmera D, Strnad H, Kolar M, Vlcek C, Petrak J, Benes J Jr, Papousek F, Oliyarnyk O, Kazdova L, Cervenka L. Metabolic characterization of volume overload heart failure due to aorto-caval fistula in rats. Mol Cell Biochem 354(1-2): 83-96, 2011.

Petrak J, Pospisilova J, Sedinova M, Jedelsky P, Lorkova L, Vit O, Kolar M, Strnad H, Benes J, Sedmera D, Cervenka L and Melenovsky V. Proteomic and transcriptomic analysis of heart failure due to volume overload in a rat aorto-caval fistula model provides support for new potential therapeutic targets - monoamine oxidase A and transglutaminase 2. Proteome Science 9(1):69, 2011.

List of all publications via PubMed

Position available for postdoctoral fellows

Collaboration with The Czech Academy of Sciences

Main topics and interest

Developmental biology
Congenital anomaliest
Cardiac conduction system

Back to the Top

© Institute of Anatomy