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Prof. David Sedmera, MD., DSc.

Prof. MUDr. David Sedmera, DSc. Mailing adress

Institute of Anatomy,
First Faculty of Medicine,
Charles University
U nemocnice 3,
128 00 Prague 2
Czech Republic

phone: +420 224 965 941


August 14, 1971


1989 - 1996: Charles University, First Faculty of Medicine - MD.
1996 - 1998: Universite de Lausanne, Faculty of Sciences - Ph.D.
2006 - First Faculty of Medicine, Charles University - Associate Professor
2009 - The Czech Academy of Sciences (CAS) - DSc.
2012 - First Faculty of Medicine, Charles University - Professor

Professional history

1996 - Institute of Experimental Medicine, CAS - Research Assistant
1996 - 1998: Institute of Physiology, University Of Lausanne - Assistant
1998 - 2000: Department of Cell Biology and Anatomy, Mediccal University of South Carolina - Postdoctoral Fellow
2000 - 2005: Department of Cell Biology and Anatomy, Mediccal University of South Carolina - Assistant Professor
2006 - 2008: Laboratory of Cardiovascular Morphogenesis, Institute of Animal Physiology and Genetics, CAS - Laboratory Head
2006 - 2012: Institute of Anatomy, First Faculty of Medicine, Charles University - Associate Professor
2008 - present: Laboratory of Cardiovascular Morphogenesis, Institute of Physiology, CAS - Laboratory Head
2012 - present: Institute of Anatomy, First Faculty of Medicine, Charles University - Professor


1994 - Department of Anatomy and Embryology, Universite Libre de Bruxelles, Belgie
1994 - 1995: Institute of Histology, Université de Lausanne, Switzerland


Beware of the crocodile wave!

Select publications


Sedmera D, Neckar J, Benes J Jr, Pospisilova J, Petrak J, Sedlacek K, Melenovsky V. Changes in Myocardial Composition and Conduction Properties in Rat Heart Failure Model Induced by Chronic Volume Overload. Front Physiol. 2016 Aug 25;7:367.

Vrbacký M, Kovalčíková J, Chawengsaksophak K, Beck IM, Mráček T, Nůsková H, Sedmera D, Papoušek F, Kolář F, Sobol M, Hozák P, Sedlacek R, Houštěk J. Knockout of Tmem70 alters biogenesis of ATP synthase and leads to embryonal lethality in mice. Hum Mol Genet. 2016 Aug 31. pii: ddw295. [Epub ahead of print]

Kolesová H, Čapek M, Radochová B, Janáček J, Sedmera D. Comparison of different tissue clearing methods and 3D imaging techniques for visualization of GFP-expressing mouse embryos and embryonic hearts. Histochem Cell Biol. 2016 Aug;146(2):141-52.

Vostarek F, Svatunkova J, Sedmera D. Acute temperature effects on function of the chick embryonic heart. Acta Physiol (Oxf). 2016 Aug;217(4):276-86.

Krejci E, Pesevski Z, Nanka O, Sedmera D. Physiological role of FGF signaling in growth and remodeling of developing cardiovascular system. Physiol Res. 2016 Jul 18;65(3):425-35.

Kockova R, Kacer P, Pirk J, Maly J, Sukupova L, Sikula V, Kotrc M, Barciakova L, Honsova E, Maly M, Kautzner J, Sedmera D, Penicka M. Native T1 Relaxation Time and Extracellular Volume Fraction as Accurate Markers of Diffuse Myocardial Fibrosis in Heart Valve Disease - Comparison With Targeted Left Ventricular Myocardial Biopsy. Circ J. 2016 Apr 25;80(5):1202-9.

Pérez-Pomares JM, de la Pompa JL, Franco D, Henderson D, Ho SY, Houyel L, Kelly RG, Sedmera D, Sheppard M, Sperling S, Thiene G, van den Hoff M, Basso C. Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology--a position statement of the development, anatomy, and pathology ESC Working Group. Cardiovasc Res. 2016 Feb 1;109(2):204-16.


Sedmera D, Kockova R, Vostarek F, Raddatz E. Arrhythmias in the developing heart.
Acta Physiol (Oxf). 2015 Feb;213(2):303-20.

Petrovova E, Purzyc H, Mazensky D, Luptakova L, Torma N, Sopoliga I, Sedmera D. Morphometric alterations, steatosis, fibrosis and active caspase-3 detection in carbamate bendiocarb treated rabbit liver. Environ Toxicol. 2015 Feb;30(2):212-22.


Sedmera D, Kockova R, Vostarek F, Raddatz E. Arrhythmias in the developing heart. Acta Physiol (Oxf). 2015 Feb;213(2):303-20. Review.

Tenin G, Clowes C, Wolton K, Krejci E, Wright JA, Lovell SC, Sedmera D, Hentges KE. Erbb2 is required for cardiac atrial electrical activity during development. PLoS One. 2014 Sep 30;9(9):e107041.

Hejnova L, Hahnova K, Kockova R, Svatunkova J, Sedmera D, Novotny J. Adenylyl cyclase signaling in the developing chick heart: the deranging effect of antiarrhythmic drugs. Biomed Res Int. 2014;2014:463123.

Vostarek F, Sankova B, Sedmera D. Studying dynamic events in the developing myocardium. Prog Biophys Mol Biol. 2014 Aug;115(2-3):261-9.

Ostadal B, Ostadalova I, Kolar F, Sedmera D. Developmental determinants of cardiac sensitivity to hypoxia. Can J Physiol Pharmacol. 2014 Jul;92(7):566-74.

Sedmera D, Gourdie RG. Why do we have Purkinje fibers deep in our heart? Physiol Res. 2014;63 Suppl 1:S9-18. Review.

Bohuslavova R, Kolar F, Sedmera D, Skvorova L, Papousek F, Neckar J, Pavlinkova G. Partial deficiency of HIF-1? stimulates pathological cardiac changes in streptozotocin-induced diabetic mice. BMC Endocr Disord. 2014 Feb 6;14:11.

Benes J Jr, Ammirabile G, Sankova B, Campione M, Krejci E, Kvasilova A, Sedmera D. The role of connexin40 in developing atrial conduction. FEBS Lett. 2014 Apr 17;588(8):1465-9.

Sochman J, Peregrin JH, Pavcnik D, Uchida BT, Timmermans HA, Sedmera D, Benada O, Kofronova O, Keller FS, Rosch J. Reverse endoventricular artificial obturator in tricuspid valve position. Experimental feasibility research study. Physiol Res. 2014;63(2):157-65.

A. HAQUE, B. ŠANKOVÁ, A. KVASILOVÁ, E. KREJČÍ, D. SEDMERA. Does Folic Acid Supplementation Rescue Defects in ECE-1-Deficient Mouse Embryos? Folia Biol (Praha). 2014;60(5):244-51.

Sedmera D. New role for endothelin signalling during development. Acta Physiol (Oxf). 2014 Feb;210(2):236-8.


Bohuslavova R, Skvorova L, Sedmera D, Semenza GL, Pavlinkova G. Increased susceptibility of HIF-1alpha heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. J Mol Cell Cardiol. 2013 Jul;60:129-41.

de la Rosa AJ, Dominguez JN, Sedmera D, Sankova B, Hove-Madsen L, Franco D, Aranega A. Functional suppression of Kcnq1 leads to early sodium channel remodeling and cardiac conduction system dysmorphogenesis. Cardiovasc Res. 2013 Jun 1;98(3):504-14.

Kockova R, Svatunkova J, Novotny J, Hejnova L, Ostadal B, Sedmera D. Heart rate changes mediate the embryotoxic effect of antiarrhythmic drugs in the chick embryo. Am J Physiol Heart Circ Physiol. 2013 Mar 15;304(6):H895-902.

Buffinton CM, Faas D, Sedmera D. Stress and strain adaptation in load-dependent remodeling of the embryonic left ventricle. Biomech Model Mechanobiol. 2013 Oct;12(5):1037-51.

List of all publications via PubMed

Collaboration with The Czech Academy of Sciences

Main topics and interest

Developmental biology
Congenital anomaliest
Cardiac conduction system

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