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INSTITUTE OF ANATOMY FIRST FACULTY OF MEDICINE
CHARLES UNIVERSITY

Prof. Miloš Grim, MD., DSc.

Prof. MUDr. Miloš Grim, DrSc. Mailing adress

First Faculty of Medicine,
Charles University
U nemocnice 3,
128 00 Praha 2
Czech Republic

Milos.Grim@lf1.cuni.cz
phone: +420 224 965 769

Born

January 18, 1941 in Rychnov nad Kněžnou

Degrees

1958-1963 - Charles University, Faculty Of Medicine - MD.
1977 - Charles University, Faculty Medicine - PhD.
2001 - Charles University, Third Faculty of Medicine - DSc.

Professional history

1963 - 1966 - Institute of Anatomy, Faculty Of Medicine - Assistant
1966 - 1987 - Institute of Anatomy, Faculty Of Medicine - Assistant Professor
1987 - 2003 - Institute of Anatomy, Faculty Of Medicine - Associate Professor
2003 - present - Institute of Anatomy, First Faculty Of Medicine - Professor
1997 - 2011 - Chairman of the Institute of Anatomy

Scholarships

1987 - Dept. of Anatomy and Cell Biology, University of Michigan, Ann Arbor
1990 - 1991 - Institute of Anatomy, Albert-Ludwigs-University, Freiburg i. B. , Germany
1992 - Visiting Professor, Institute of Anatomy, University of Zürich, Switzerland

Publications

List of papers via PubMed

Select publications

Szeder V, Grim M, Halata Z, Sieber-Blum M: Neural Crest Origin of Mammalian Merkel Cells. Dev Biol 253: 258 - 263, 2003 +

M. Sieber-Blum, M. Grim, Y.F. Hu, and V. Szeder: Pluripotent Neural Crest Stem Cells in the Adult Hair Follicle. Dev. Dynamics 231: 258–269, 2004 +

Valasek P, Evans DJR, Maina F, Grim M, Patel K: A dual fate of the hindlimb muscle mass: cloacal/perineal musculature develops from leg muscle cells. Development 132: 447- 458, 2005

Karafi at V., Dvorakova M., Krejci E., Kralova J., Pajer P., Snajdr P., Mandikova S., Bartunek P., Grim M. and Dvorak: Transcription factor c-Myb is involved in the regulation of the epithelial-mesenchymal transition in the avian neural crest. M. Cell. Mol. Life Sci. 62 (2005) 2516–2525 +

Naňka O, Valasek O, Dvořáková M, Grim M: Experimental hypoxia and embryonic angiogenesis. Developmental Dynamics 235:723–733, 2006 +

Sieber-Blum M, Schnell L, Grim M, Schneider R, Schwab ME: Characterization of epidermal neural crest stem cell (EPI-NCSC) grafts in the lesioned spinal cord. Mol Cell Neurosci 32: 67 - 81, 2006

Kolesová H, Roelink H, Grim M: Sonic Hedgehog Is Required for the Assembly and Remodeling of Branchial Arch Blood Vessels. Dev Dyn 237:1923–1934, 2008 + Dev Dyn

Nanka O, Krizova P, Fikrle M, Tuma M, Blaha M, Grim M, Sedmera D: Abnormal myocardial and coronary vasculature development in experimental hypoxia. Anat Rec, 2008, 291: 1187 - 1199.

Liska F, Snajdr P, Sedová L, Seda O, Chylíkova B, Slamová P, Krejcí E, Sedmera D, Grim M, Krenova D, Kren V: Deletion of a conserved noncoding sequence in Plzf intron leads to Plzf down-regulation in limb bud and polydactyly in the rat. Dev Dyn, 2009, 238: 673 -684

Valasek P, Theis S, Krejci E, Grim M, Maina F, Shwartz Y, Otto A, Huang R, Patel K: Somitic origin of the medial border of the mammalian scapula and its homology to the avian scapula blade. J Anat, 2010, 216: 482 – 488

Krejčí E, Grim M: Isolation and characterization of neural crest stem cells from adult human hair follicles. Folia Biol (Praha) 2010, 56: 149 – 157

Patent

United States Patent No.: US 8,030,072 B2 Date of Patent Oct. 4, 2011
METHOD OF ISOLATING OF EPIDERMAL NEURAL CREST STEM CELLS

Inventors: Maya Sieber-Blum, Brookfield, WI (US), Milos Grim, Prague (CZ)
Assignees: Newcastle University, New Castle Upon Tyne (GB); Univerzita Karlova v Praze, Prague (CZ)

Abstract
The present invention describes novel methods for isolating a substantialy pure cell population of non-embryonic epidermal neural crest stem cells from the bulge-region of mammalian hair follicles. Also disclosed is the substantially pure cell population of follicular bulge-derived neural crest stem cells for medical research anf therapeutic use.

New Trends 2015

Main topics and interest

developmental biology
muscle development
angiogenesis, vasculogenesis
development of mechanoreceptors
migration and differentiation of neural crest cells
neural crest stem cells

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